Dr. Philipp Skroblin
Education
| 2000-2006 | Diplom (MSc equivalent) in Biochemistry Freidrich-Schiller-University Jena, Germany |
| 2007-2011 | PhD in Biochemistry Free University Berlin/Leibniz Institute for Molecular Pharmacology, Berlin, Germany |
Present Appointment
| 2012- | Research Associate Cardiovascular Division, King’s College London, London, UK |
Previous Appointment
| 2011-2012 | Postdoctoral Researcher Max Delbrück Center for Molecular Medicine, Berlin, Germany |
Awards & Prizes
| 2015 | NIHR Guy’s and St Thomas’ Biomedical Research Centre School of Translational and Experimental Medicine Early Career Award 2015 (£ 10,000 for training and research) |
Publications
| 1 | Yin X, Wanga S, Fellows AL, Barallobre-Barreiro J, Lu R, Davaapil H, Franken R, Fava M, Baig F, Skroblin P, Xing Q, Koolbergen DR, Groenink M, Zwinderman AH, Balm R, de Vries CJM, Mulder BJM, Viner R, Jahangiri M, Reinhardt DP, Sinha S, de Waard V, Mayr M.. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.. Arterioscler Thromb Vasc Biol.. 2019 39(9) : 1859-1873. [Full Text] [PubMed] [DOI] |
| 2 | Willeit K, Pechlaner R, Willeit P, Skroblin P, Paulweber B, Schernthaner C, Toell T, Egger G, Weger S, Oberhollenzer M, Kedenko L, Iglseder B, Bonora E, Schett G, Mayr M, Willeit J, Kiechl S. Association Between Vascular Cell Adhesion Molecule 1 and Atrial Fibrillation. JAMA Cardiol. 2017 5 : 516-523. [PubMed] [DOI] |
| 3 | Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017 4 : 1546-1560. [Full Text] [PubMed] [DOI] |
| 4 | Sunderland N, Skroblin P, Barwari T, Huntley RP, Lu R, Joshi A, Lovering RC, Mayr M. MicroRNA Biomarkers and Platelet Reactivity: The Clot Thickens. Circ Res. 2017 20 : 418-435. [Full Text] [PubMed] [DOI] |
| 5 | Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C. Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium. J Am Coll Cardiol. 2017 69 : 131-143. [Full Text] [PubMed] [DOI] |
| 6 | Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramírez CM, Goedeke L, Rotllan N, Bonora E, Hughes AD, Santer P, Fernández-Hernando C, Tilg H, Willeit J, Kiechl S, Mayr M.. Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. Diabetes. 2017 66 : 347-357. [Full Text] [PubMed] [DOI] |
| 7 | Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 8 : 643-653. [Full Text] [PubMed] [DOI] |
| 8 | Willeit P, Skroblin P, Kiechl S, Fernández-Hernando C, Mayr M. Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?. Eur Heart J. 2016 14 : 3260-3266. [Full Text] [PubMed] [DOI] |
| 9 | Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock LR, Fischer JW. Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 36 : 41-50. [Full Text] [PubMed] [DOI] |
| 10 | Barwari T, Skroblin P, Mayr M. When Sweet Turns Salty: Glucose-Induced Suppression of Atrial Natriuretic Peptide by MicroRNA-425. J Am Coll Cardiol. 2016 67 : 813-816. [Full Text] [PubMed] [DOI] |
| 11 | Gomes RS, Skroblin P, Munster AB, Tomlins H, Langley SR, Zampetaki A, Yin X, Wardle FC, Mayr M. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016 92 : 105-108. [Full Text] [PubMed] [DOI] |
| 12 | Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Association of MicroRNAs and YRNAs With Platelet Function. Circ Res. 2016 118 : 420-432. [Full Text] [PubMed] [DOI] |
| 13 | Deák VA, Skroblin P, Dittmayer C, Knobeloch KP, Bachmann S, Klussmann E. The A-kinase anchoring protein GSKIP regulates GSK3beta activity and controls palatal shelf fusion in mice. J Biol Chem. 2015 Epub : Ahead of Print. [PubMed] [DOI] |
| 14 | Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW. Neurochondrin is an atypical RIIalpha-specific A-kinase anchoring protein. Biochim Biophys Acta. 2015 1854 : 1667-1675. [PubMed] [DOI] |
| 15 | Poppinga WJ, Heijink IH, Holtzer LJ, Skroblin P, Klussmann E, Halayko AJ, Timens W, Maarsingh H, Schmidt M. A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015 308 : L766-L775. [PubMed] [DOI] |
| 16 | Skroblin P, Mayr M. "Going Long": Long Non-Coding RNAs as Biomarkers. Circ Res. 2014 115 : 607-609. [Full Text] [PubMed] [DOI] |
| 17 | Scheunemann L, Skroblin P, Hundsrucker C, Klussmann E, Efetova M, Schwärzel M. AKAPS act in a two-step mechanism of memory acquisition. J Neurosci. 2013 33 : 17422-17428. [PubMed] [DOI] |
| 18 | Abdulkareem N, Skroblin P, Jahangiri M, Mayr M. Proteomics in aortic aneurysm - What have we learnt so far?. Proteomics Clin Appl. 2013 7 : 504-515. [Full Text] [PubMed] [DOI] |
| 19 | Willoughby D, Halls ML, Everett KL, Ciruela A, Skroblin P, Klussmann E, Cooper DM. A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex. J Cell Sci. 2012 125 : 5850-5859. [PubMed] [DOI] |
| 20 | Willoughby D, Everett KL, Halls ML, Pacheco J, Skroblin P, Vaca L, Klussmann E, Cooper DM. Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling. Sci Signal. 2012 5 : ra29. [PubMed] [DOI] |
| 21 | Tröger J, Moutty MC, Skroblin P, Klussmann E. A-kinase anchoring proteins as potential drug targets. Br J Pharmacol. 2012 166 : 420-433. [PubMed] [DOI] |
| 22 | Skroblin P, Grossmann S, Schäfer G, Rosenthal W, Klussmann E. Mechanisms of protein kinase A anchoring. Int Rev Cell Mol Biol. 2010 283 : 235-330. [PubMed] [DOI] |
| 23 | Nedvetsky PI, Tabor V, Tamma G, Beulshausen S, Skroblin P, Kirschner A, Mutig K, Boltzen M, Petrucci O, Vossenkämper A, Wiesner B, Bachmann S, Rosenthal W, Klussmann E. Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol. 2010 21 : 1645-1656. [PubMed] [DOI] |
| 24 | Hundsrucker C, Skroblin P, Christian F, Zenn HM, Popara V, Joshi M, Eichhorst J, Wiesner B, Herberg FW, Reif B, Rosenthal W, Klussmann E. Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem. 2010 285 : 5507-5521. [PubMed] [DOI] |
| 25 | Lehmann K, Müller JP, Schlott B, Skroblin P, Barz D, Norgauer J, Wetzker R. PI3Kgamma controls oxidative bursts in neutrophils via interactions with PKCalpha and p47phox. Biochem J. 2009 419 : 603-610. [PubMed] [DOI] |